miR-15a and miR-16-1 in cancer: discovery, function and future perspectives

被引：532

作者：

Aqeilan, R. I. ^{[1
,2
]}

Calin, G. A. ^{[3
]}

Croce, C. M. ^{[2
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Inst Med Res Israel Canada, Lautenberg Ctr Gen & Tumor Immunol, IL-91120 Jerusalem, Israel

[2] Ohio State Univ, Ctr Comprehens Canc, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA

来源：

CELL DEATH AND DIFFERENTIATION | 2010年 / 17卷 / 02期

关键词：

microRNA; BCL2; CLL; apoptosis; miR15/16; cluster; CHRONIC LYMPHOCYTIC-LEUKEMIA; HUMAN LUNG CANCERS; MICRORNA EXPRESSION; HEPATOCELLULAR-CARCINOMA; DOWN-REGULATION; 13Q14; APOPTOSIS; GENE; DEREGULATION; PROFILES;

D O I：

10.1038/cdd.2009.69

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) encoded by the miR-15/16 cluster are known to act as tumor suppressors. Expression of these miRNAs inhibits cell proliferation, promotes apoptosis of cancer cells, and suppresses tumorigenicity both in vitro and in vivo. miR-15a and miR-16-1 function by targeting multiple oncogenes, including BCL2, MCL1, CCND1, and WNT3A. Down-regulation of these miRNAs has been reported in chronic lymphocytic lymphoma (CLL), pituitary adenomas, and prostate carcinoma. This review summarizes the discovery, functions, and clinical relevance of these miRNAs in cancer, particularly CLL. Cell Death and Differentiation (2010) 17, 215-220; doi:10.1038/cdd.2009.69; published online 5 June 2009

引用

页码：215 / 220

页数：6

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