Modeling traffic jams in intracellular transport in axons

Irregularities in intracellular traffic in axons caused by mutations of molecular motors may lead to "traffic jams", which often result in swelling of axons causing various neurodegenerative diseases. The purpose of this paper is to suggest a model of the formation of traffic jams in axons during molecular-motor-assisted transport of intracellular organelles utilizing transport equations developed in Smith and Simmons [D.A. Smith, R.M. Simmons, Models of motor-assisted transport of intracellular particles, Biophys. J. 80 (2001) 45-68], which describe the motion of intracellular particles under the combined action of diffusion and motor-driven transport. According to this model, large intracellular organelles are transported in the cytoplasm by a combined action of diffusion and motor-driven transport. In an axon, organelles are transported away from the neuron's body toward the axon's terminal by kinesin-family molecular motors running on tracks composed by microtubules: old and used components are carried back toward neuron's body by dynein-family molecular motors. Binding/detachment kinetic processes between the organelles and microtubules are specified by first rate reaction constants; these lead to coupling between the three organelle concentrations. (C) 2008 Elsevier Ltd. All rights reserved.