Theory of spatial patterns of intracellular organelles

被引：21

作者：

Dinh, AT ^{[1
]}

Pangarkar, C ^{[1
]}

Theofanous, T ^{[1
]}

Mitragotri, S ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA

来源：

BIOPHYSICAL JOURNAL | 2006年 / 90卷 / 10期

关键词：

D O I：

10.1529/biophysj.106.082875

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Here we report on a generalized theory of spatial patterns of intracellular organelles, which are controlled by cells using cytoskeleton-based movements powered by molecular motors. The theory reveals that organelles exhibit one of the four distinct, stable patterns, namely aggregation, hyperdispersion, radial dispersion, and areal dispersion. Existence of specific patterns is determined by the contributions from three transport mechanisms, characterized by two Peclet numbers. The predicted patterns compare well with experimental data. This study provides a firm theoretical ground for classification of spatial patterns of organelles and understanding their regulation by cells.

引用

页码：L67 / L69

页数：3

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