Neurodegenerative disorders:: the role of peroxynitrite

被引:360
作者
Torreilles, F
Salman-Tabcheh, S
Guérin, MC
Torreilles, J
机构
[1] Univ Montpellier 2, IFR Eugene Bataillon 56, F-34095 Montpellier 5, France
[2] UFR Pharm, CNRS UMR 9921, F-34060 Montpellier, France
关键词
Alzheimer's disease; Parkinson's disease; multiple sclerosis; amyotrophic lateral sclerosis; peroxynitrite;
D O I
10.1016/S0165-0173(99)00014-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Inflammatory reaction is thought to be an important contributor to neuronal damage in neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and the parkinsonism dementia complex of Guam, Among the toxic agents released in brain tissues by activated cells, we focus attention in this review on peroxynitrite, the product of the reaction between nitric oxide (NO) and superoxide. Peroxynitrite is a strong oxidizing and nitrating agent which can react with all classes of biomolecules. In the CNS it can be generated by microglial cells activated by pro-inflammatory cytokines or beta-amyloid peptide (beta-A) and by neurons in three different situations: hyperactivity of glutamate neurotransmission: mitochondrial dysfunction and depletion of L-arginine or tetrahydrobiopterin. The first two situations correspond to cellular responses to an initial neuronal injury and the peroxynitrite formed only exacerbates the inflammatory process, whereas in the third situation the peroxynitrite generated directly contributes to the initiation of the neurodegenerative process. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:153 / 163
页数:11
相关论文
共 95 条
  • [31] Tetrahydrobiopterin-free neuronal nitric oxide synthase: Evidence for two identical highly anticooperative pteridine binding sites
    Gorren, ACF
    List, BM
    Schrammel, A
    Pitters, E
    Hemmens, B
    Werner, ER
    Schmidt, K
    Mayer, B
    [J]. BIOCHEMISTRY, 1996, 35 (51) : 16735 - 16745
  • [32] Gorren ACF, 1998, BIOCHEMISTRY-MOSCOW+, V63, P734
  • [33] Gurwitz D, 1998, EUR J CLIN INVEST, V28, P760
  • [34] Hensley K, 1998, J NEUROSCI, V18, P8126
  • [35] Amyloid-β peptide activates cultured astrocytes:: morphological alterations, cytokine induction and nitric oxide release
    Hu, JG
    Akama, KT
    Krafft, GA
    Chromy, BA
    Van Eldik, LJ
    [J]. BRAIN RESEARCH, 1998, 785 (02) : 195 - 206
  • [36] THE REACTION OF NO WITH SUPEROXIDE
    HUIE, RE
    PADMAJA, S
    [J]. FREE RADICAL RESEARCH COMMUNICATIONS, 1993, 18 (04): : 195 - 199
  • [37] beta-Amyloid protein-dependent nitric oxide production from microglial cells and neurotoxicity
    Ii, M
    Sunamoto, M
    Ohnishi, K
    Ichimori, Y
    [J]. BRAIN RESEARCH, 1996, 720 (1-2) : 93 - 100
  • [38] PEROXYNITRITE FORMATION FROM MACROPHAGE-DERIVED NITRIC-OXIDE
    ISCHIROPOULOS, H
    ZHU, L
    BECKMAN, JS
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1992, 298 (02) : 446 - 451
  • [39] Understanding cell death in Parkinson's disease
    Jenner, P
    Olanow, CW
    [J]. ANNALS OF NEUROLOGY, 1998, 44 (03) : S72 - S84
  • [40] JENNER P, 1996, NEUROLOGY S3, V47, P161