The PAZAR database of gene regulatory information coupled to the ORCA toolkit for the study of regulatory sequences

被引:87
作者
Portales-Casamar, Elodie [1 ]
Arenillas, David [1 ]
Lim, Jonathan [1 ]
Swanson, Magdalena I. [1 ]
Jiang, Steven [1 ]
McCallum, Anthony [1 ]
Kirov, Stefan [2 ]
Wasserman, Wyeth W. [1 ]
机构
[1] Univ British Columbia, Dept Med Genet, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 1M9, Canada
[2] Pharmaceut Res Inst, Appl Genom Dept, Bristol, NJ USA
基金
加拿大创新基金会;
关键词
TRANSCRIPTION; ALIGNMENT; FRAMEWORK; ELEMENTS; SEARCH;
D O I
10.1093/nar/gkn783
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The PAZAR database unites independently created and maintained data collections of transcription factor and regulatory sequence annotation. The flexible PAZAR schema permits the representation of diverse information derived from experiments ranging from biochemical protein-DNA binding to cellular reporter gene assays. Data collections can be made available to the public, or restricted to specific system users. The data 'boutiques' within the shopping-mall-inspired system facilitate the analysis of genomics data and the creation of predictive models of gene regulation. Since its initial release, PAZAR has grown in terms of data, features and through the addition of an associated package of software tools called the ORCA toolkit (ORCAtk). ORCAtk allows users to rapidly develop analyses based on the information stored in the PAZAR system. PAZAR is available at http://www.pazar.info. ORCAtk can be accessed through convenient buttons located in the PAZAR pages or via our web-site at http://www.cisreg.ca/ORCAtk.
引用
收藏
页码:D54 / D60
页数:7
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