Non-antioxidant molecular functions of α-tocopherol (vitamin E)

被引：237

作者：

Azzi, A ^{[1
]}

Ricciarelli, R

Zingg, JM

机构：

[1] Univ Bern, Inst Biochem & Mol Biol, Buhlstr 28, CH-3012 Bern, Switzerland

[2] Univ Genoa, Dipartimento Med Sperimentale, I-16132 Genoa, Italy

来源：

FEBS LETTERS | 2002年 / 519卷 / 1-3期

关键词：

alpha-tocopherol; non-antioxidant mechanism; protein kinase C; cell proliferation; gene expression; platelet aggregation; oxygen burst;

D O I：

10.1016/S0014-5793(02)02706-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

alpha-Tocopherol (the major vitamin E component) regulates key cellular events by mechanisms unrelated with its antioxidant function. Inhibition of protein kinase C (PKC) activity and vascular smooth muscle cell growth by alpha-tocopherol was first described by our group. Later, alpha-tocopherol was shown to inhibit PKC in various cell types with consequent inhibition of aggregation in platelets, of nitric oxide production in endothelial cells and of superoxide production in neutrophils and macrophages. alpha-Tocopherol diminishes adhesion molecule, collagenase and scavenger receptor (SR-A and CD36) expression and increases connective tissue growth factor expression. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：8 / 10

页数：3

共 52 条

[1] Modulation of α-tropomyosin expression by α-tocopherol in rat vascular smooth muscle cells
Aratri, E
Spycher, SE
Breyer, I
Azzi, A
[J]. FEBS LETTERS, 1999, 447 (01) : 91 - 94
[2] DISTRIBUTION OF ALPHA-TOCOPHEROL IN HUMAN-PLASMA LIPOPROTEINS
BEHRENS, WA
THOMPSON, JN
MADERE, R
[J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1982, 35 (04) : 691 - 696
[3] LOCALIZATION OF FRIEDREICH ATAXIA PHENOTYPE WITH SELECTIVE VITAMIN-E-DEFICIENCY TO CHROMOSOME-8Q BY HOMOZYGOSITY MAPPING
BENHAMIDA, C
DOERFLINGER, N
BELAL, S
LINDER, C
REUTENAUER, L
DIB, C
GYAPAY, G
VIGNAL, A
LEPASLIER, D
COHEN, D
PANDOLFO, M
MOKINI, V
NOVELLI, G
HENTATI, F
BENHAMIDA, M
MANDEL, JL
KOENIG, M
[J]. NATURE GENETICS, 1993, 5 (02) : 195 - 200
[4] BOSCOBOINIK D, 1991, J BIOL CHEM, V266, P6188
[5] Differential inhibition by α- and β-tocopherol of human erythroleukemia cell adhesion:: Role of integrins
Breyer, I
Azzi, A
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 2001, 30 (12) : 1381 - 1389
[6] α-tocopherol inhibits the respiratory burst in human monocytes -: Attenuation of p47phox membrane translocation and phosphorylation
Cachia, O
El Benna, J
Pedruzzi, E
Descomps, B
Gougerot-Pocidalo, MA
Leger, CL
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (49) : 32801 - 32805
[7] The effect of alpha-tocopherol on the synthesis, phosphorylation and activity of protein kinase C in smooth muscle cells after phorbol 12-myristate 13-acetate down-regulation
Clement, S
Tasinato, A
Boscoboinik, D
Azzi, A
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 246 (03): : 745 - 749
[8] Localization of α-tocopherol transfer protein in the brains of patients with ataxia with vitamin E deficiency and other oxidative stress related neurodegenerative disorders
Copp, RP
Wisniewski, T
Hentati, F
Larnaout, A
Ben Hamida, M
Kayden, HJ
[J]. BRAIN RESEARCH, 1999, 822 (1-2) : 80 - 87
[9] Oxidized low density lipoprotein and atherosclerosis
Devaraj, S
Jialal, I
[J]. INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH, 1996, 26 (03) : 178 - 184
[10] Devaraj S, 2001, J LIPID RES, V42, P521

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