Decomposition of thymidine by low-energy electrons:: Implications for the molecular mechanisms of single-strand breaks in DNA

被引：111

作者：

Ptasinska, S

Denifl, S

Gohlke, S

Scheier, P

Illenberger, E

Märk, TD

机构：

[1] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany

[2] Univ Innsbruck, Inst Ionenphys & Angew Phys, A-6020 Innsbruck, Austria

[3] Ctr Mol Biosci Innsbruck, A-6020 Innsbruck, Austria

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 12期

关键词：

anions; DNA damage; electron attachment; gas-phase reactions; nucleotides;

D O I：

10.1002/anie.200503930

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The damage to biological systems by high-energy quanta occurs mainly through secondary species created in the ionization path. Interaction of the low-energy (0-3 eV) electrons with thymidine (Td) in the gas phase was investigated. These electrons induce loss of hydrogen from the N3 position and scission of the N1-C1 bond. The transfer of excess electrons, initially localized on thymine, to the sugar moiety was not observed. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1893 / 1896

页数：4

共 21 条

[1] Site-specific dissociation of DNA bases by slow electrons at early stages of irradiation [J].