Inference of DNA sequences from mechanical unzipping: An ideal-case study

被引：25

作者：

Baldazzi, V ^{[1
]}

Cocco, S

Marinari, E

Monasson, R

机构：

[1] Univ Roma Tor Vergata, Dipartimento Fis, I-00173 Rome, Italy

[2] ENS, Phys Stat Lab, CNRS, F-75005 Paris, France

[3] ENS, Theoret Phys Lab, CNRS, F-75005 Paris, France

[4] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy

[5] Univ Roma La Sapienza, Ist Nazl Fis Nucl, I-00185 Rome, Italy

来源：

PHYSICAL REVIEW LETTERS | 2006年 / 96卷 / 12期

关键词：

D O I：

10.1103/PhysRevLett.96.128102

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

The performances of Bayesian inference to predict the sequence of DNA molecules from fixed-force unzipping experiments are investigated. We show that the probability of misprediction decreases exponentially with the amount of collected data. The decay rate is calculated as a function of biochemical parameters (binding free energies), the sequence content, the applied force, the elastic properties of a DNA single strand, and time resolution.

引用

页数：4

共 27 条

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