Targets of checkpoints controlling mitosis: Lessons from lower eukaryotes

被引：22

作者：

Osmani, SA

Ye, XS

机构：

[1] Weis Center for Research, Geisinger Clinic, Danville

来源：

TRENDS IN CELL BIOLOGY | 1997年 / 7卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0962-8924(97)01086-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Prevention of mitosis if DNA is damaged, or not fully replicated, is a widespread mechanism used by eukaryotic cells to maintain their ploidy and prevent accumulation of mutations. such 'checkpoints' must inhibit mitotic regulators to prevent mitotic progression when DNA is not ready for segregation. The mitotic regulators targeted for negative regulation by these checkpoints differ among cell types, but two conserved targets have emerged the anaphase-promoting complex (APC) and tyrosine phosphorylation of p34(cdc2). One potential downstream target of both these regulators has also been identified the mitosis-promoting NIMA kinase.

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收藏

页码：283 / 288

页数：6

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