Chiral polyesters by dynamic kinetic resolution polymerization

被引：63

作者：

Hilker, I

Rabani, G

Verzijl, GKM

Palmans, ARA

Heise, A

机构：

[1] DSM Res & Patents, NL-6160 MD Geleen, Netherlands

[2] Tech Univ Eindhoven, Lab Macromol & Organ Chem, NL-5600 MB Eindhoven, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 13期

关键词：

chiral resolution; enzyme catalysis; polymerization;

D O I：

10.1002/anie.200503496

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Problem resolved: Enzymatic polymerization was combined with an in situ Rucatalyzed racemization process. The reaction mixture comprises a racemic mixture of a chiral diol and dimethyl adipate. Because of the high stereoselectivity of the enzyme Candida antarctica lipase B (CALB), the S-configured stereocenters of the chiral diol are practically nonreactive. Polycondensation was achieved by concurrent racemization of the S- into the R-configured centers. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：2130 / 2132

页数：3

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