ABO Blood Type Incompatible Kidney Transplantation Without Splenectomy Prepared With Plasma Exchange and Rituximab

被引：19

作者：

Chikaraishi, T. ^{[1
]}

Sasaki, H. ^{[1
]}

Tsutsumi, H. ^{[1
]}

Miyano, S. ^{[1
]}

Nakazawa, R. ^{[1
]}

Nakano, T. ^{[1
]}

Kitajima, K. ^{[1
]}

Kudo, H. ^{[1
]}

Takahashi, T. ^{[1
]}

Sato, Y. ^{[1
]}

Kimura, K. ^{[1
]}

机构：

[1] St Marianna Univ, Dept Urol, Kawasaki Ku, Kanagawa 2168511, Japan

来源：

TRANSPLANTATION PROCEEDINGS | 2008年 / 40卷 / 10期

关键词：

D O I：

10.1016/j.transproceed.2008.06.110

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have designed a protocol for ABO-incompatible kidney transplantations based on preoperative plasmapheresis with a tacrolimus/mycophenolate mofetil/methylprednisolone/ basiliximab protocol using low-dose rituximab (200 mg/body) instead of splenectomy to prevent antibody-mediated acute rejection. Eight patients successfully received transplants with this protocol. The titers of anti-A and -B, antibodies as well as the number of CD20(+) cells were readily maintained at a low level posttransplantation. There were no side effects. All patients have renal transplant function with a follow-up of 1-34 months.

引用

页码：3445 / 3447

页数：3

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