Individualized Medicine from Prewomb to Tomb

被引：201

作者：

Topol, Eric J. ^{[1
]}

机构：

[1] Scripps Res Inst & Scripps Hlth, Scripps Translat Sci Inst, La Jolla, CA 92037 USA

来源：

CELL | 2014年 / 157卷 / 01期

关键词：

INFORMATION-STORAGE; WIDE ASSOCIATION; DNA METHYLATION; CANCER GENOME; DISEASE; RISK; ERA; MUTATIONS; LANDSCAPE; GENETICS;

D O I：

10.1016/j.cell.2014.02.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

That each of us is truly biologically unique, extending to even monozygotic, "identical'' twins, is not fully appreciated. Now that it is possible to perform a comprehensive "omic'' assessment of an individual, including one's DNA and RNA sequence and at least some characterization of one's proteome, metabolome, microbiome, autoantibodies, and epigenome, it has become abundantly clear that each of us has truly one-of-a-kind biological content. Well beyond the allure of the matchless fingerprint or snowflake concept, these singular, individual data and information set up a remarkable and unprecedented opportunity to improve medical treatment and develop preventive strategies to preserve health.

引用

页码：241 / 253

页数：13

共 101 条

[1] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[2]

Almeling R., 2013, NY TIMES

[3]

[Anonymous], 2014, NATURE NEWS

[4]

[Anonymous], WALL STREET J

[5] Enterotypes of the human gut microbiome [J].

Arumugam, Manimozhiyan ;

Raes, Jeroen ;

Pelletier, Eric ;

Le Paslier, Denis ;

Yamada, Takuji ;

Mende, Daniel R. ;

Fernandes, Gabriel R. ;

Tap, Julien ;

Bruls, Thomas ;

Batto, Jean-Michel ;

Bertalan, Marcelo ;

Borruel, Natalia ;

Casellas, Francesc ;

Fernandez, Leyden ;

Gautier, Laurent ;

Hansen, Torben ;

Hattori, Masahira ;

Hayashi, Tetsuya ;

Kleerebezem, Michiel ;

Kurokawa, Ken ;

Leclerc, Marion ;

Levenez, Florence ;

Manichanh, Chaysavanh ;

Nielsen, H. Bjorn ;

Nielsen, Trine ;

Pons, Nicolas ;

Poulain, Julie ;

Qin, Junjie ;

Sicheritz-Ponten, Thomas ;

Tims, Sebastian ;

Torrents, David ;

Ugarte, Edgardo ;

Zoetendal, Erwin G. ;

Wang, Jun ;

Guarner, Francisco ;

Pedersen, Oluf ;

de Vos, Willem M. ;

Brunak, Soren ;

Dore, Joel ;

Weissenbach, Jean ;

Ehrlich, S. Dusko ;

Bork, Peer .

NATURE, 2011, 473 (7346) :174-180

[6] Image-based transcriptomics in thousands of single human cells at single-molecule resolution [J].

Battich, Nico ;

Stoeger, Thomas ;

Pelkmans, Lucas .

NATURE METHODS, 2013, 10 (11) :1127-1133

[7] Tumour heterogeneity in the clinic [J].

Bedard, Philippe L. ;

Hansen, Aaron R. ;

Ratain, Mark J. ;

Siu, Lillian L. .

NATURE, 2013, 501 (7467) :355-364

[8] Amplifying Genetic Logic Gates [J].

Bonnet, Jerome ;

Yin, Peter ;

Ortiz, Monica E. ;

Subsoontorn, Pakpoom ;

Endy, Drew .

SCIENCE, 2013, 340 (6132) :599-603

[9] A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels [J].

Bouatia-Naji, Nabila ;

Rocheleau, Ghislain ;

Van Lommel, Leentje ;

Lemaire, Katleen ;

Schuit, Frans ;

Cavalcanti-Proenca, Christine ;

Marchand, Marion ;

Hartikainen, Anna-Liisa ;

Sovio, Ulla ;

De Graeve, Franck ;

Rung, Johan ;

Vaxillaire, Martine ;

Tichet, Jean ;

Marre, Michel ;

Balkau, Beverley ;

Weill, Jacques ;

Elliott, Paul ;

Jarvelin, Marjo-Riitta ;

Meyre, David ;

Polychronakos, Constantin ;

Dina, Christian ;

Sladek, Robert ;

Froguel, Philippe .

SCIENCE, 2008, 320 (5879) :1085-1088

[10] Rare-disease genetics in the era of next-generation sequencing: discovery to translation [J].

Boycott, Kym M. ;

Vanstone, Megan R. ;

Bulman, Dennis E. ;

MacKenzie, Alex E. .

NATURE REVIEWS GENETICS, 2013, 14 (10) :681-691

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