Individualized Medicine from Prewomb to Tomb

被引：201

作者：

Topol, Eric J. ^{[1
]}

机构：

[1] Scripps Res Inst & Scripps Hlth, Scripps Translat Sci Inst, La Jolla, CA 92037 USA

来源：

CELL | 2014年 / 157卷 / 01期

关键词：

INFORMATION-STORAGE; WIDE ASSOCIATION; DNA METHYLATION; CANCER GENOME; DISEASE; RISK; ERA; MUTATIONS; LANDSCAPE; GENETICS;

D O I：

10.1016/j.cell.2014.02.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

That each of us is truly biologically unique, extending to even monozygotic, "identical'' twins, is not fully appreciated. Now that it is possible to perform a comprehensive "omic'' assessment of an individual, including one's DNA and RNA sequence and at least some characterization of one's proteome, metabolome, microbiome, autoantibodies, and epigenome, it has become abundantly clear that each of us has truly one-of-a-kind biological content. Well beyond the allure of the matchless fingerprint or snowflake concept, these singular, individual data and information set up a remarkable and unprecedented opportunity to improve medical treatment and develop preventive strategies to preserve health.

引用

页码：241 / 253

页数：13

共 101 条

[41] A gene of rare effect [J].

Hall, Stephen S. .

NATURE, 2013, 496 (7444) :152-155

[42] The hallmarks of cancer [J].

Hanahan, D ;

Weinberg, RA .

CELL, 2000, 100 (01) :57-70

[43] Hallmarks of Cancer: The Next Generation [J].

Hanahan, Douglas ;

Weinberg, Robert A. .

CELL, 2011, 144 (05) :646-674

[44] Pharmacogenomics in clinical practice and drug development [J].

Harper, Andrew R. ;

Topol, Eric J. .

NATURE BIOTECHNOLOGY, 2012, 30 (11) :1117-1124

[45] Whole-genome sequencing for analysis of an outbreak of meticillin-resistant Staphylococcus aureus: a descriptive study [J].

Harris, Simon R. ;

Cartwright, Edward J. P. ;

Toeroek, M. Estee ;

Holden, Matthew T. G. ;

Brown, Nicholas M. ;

Ogilvy-Stuart, Amanda L. ;

Ellington, Matthew J. ;

Quail, Michael A. ;

Bentley, Stephen D. ;

Parkhill, Julian ;

Peacock, Sharon J. .

LANCET INFECTIOUS DISEASES, 2013, 13 (02) :130-136

[46] Highly Recurrent TERT Promoter Mutations in Human Melanoma [J].

Huang, Franklin W. ;

Hodis, Eran ;

Xu, Mary Jue ;

Kryukov, Gregory V. ;

Chin, Lynda ;

Garraway, Levi A. .

SCIENCE, 2013, 339 (6122) :957-959

[47] Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment [J].

Iida, Noriho ;

Dzutsev, Amiran ;

Stewart, C. Andrew ;

Smith, Loretta ;

Bouladoux, Nicolas ;

Weingarten, Rebecca A. ;

Molina, Daniel A. ;

Salcedo, Rosalba ;

Back, Timothy ;

Cramer, Sarah ;

Dai, Ren-Ming ;

Kiu, Hiu ;

Cardone, Marco ;

Naik, Shruti ;

Patri, Anil K. ;

Wang, Ena ;

Marincola, Francesco M. ;

Frank, Karen M. ;

Belkaid, Yasmine ;

Trinchieri, Giorgio ;

Goldszmid, Romina S. .

SCIENCE, 2013, 342 (6161) :967-970

[48]

Issacson W., 2011, STEVE JOBS

[49] Genomics in Clinical Practice: Lessons from the Front Lines [J].

Jacob, Howard J. ;

Abrams, Kelly ;

Bick, David P. ;

Brodie, Kent ;

Dimmock, David P. ;

Farrell, Michael ;

Geurts, Jennifer ;

Harris, Jeremy ;

Helbling, Daniel ;

Joers, Barbara J. ;

Kliegman, Robert ;

Kowalski, George ;

Lazar, Jozef ;

Margolis, David A. ;

North, Paula ;

Northup, Jill ;

Roquemore-Goins, Altheia ;

Scharer, Gunter ;

Shimoyama, Mary ;

Strong, Kimberly ;

Taylor, Bradley ;

Tsaih, Shirng-Wern ;

Tschannen, Michael R. ;

Veith, Regan L. ;

Wendt-Andrae, Jaime ;

Wilk, Brandon ;

Worthey, Elizabeth A. .

SCIENCE TRANSLATIONAL MEDICINE, 2013, 5 (194)

[50]

Jenkins Holman W., 2010, Wall Street Journal

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