Testosterone attenuates β-amyloid toxicity in cultured hippocampal neurons

被引：182

作者：

Pike, CJ ^{[1
]}

机构：

[1] Univ So Calif, Andrus Gerontol Ctr, Los Angeles, CA 90089 USA

来源：

BRAIN RESEARCH | 2001年 / 919卷 / 01期

关键词：

androgen; testosterone; neuroprotection; beta-amyloid; Alzheimer's disease;

D O I：

10.1016/S0006-8993(01)03024-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Accumulating evidence suggests that testosterone has, neurotrophic and perhaps neuroprotective actions. Thus, age-related depletion of testosterone may increase the brain's vulnerability to Alzheimer's disease and related disorders. To begin investigating this issue, cultured neurons were exposed to, the Alzheimer-related insult beta -amyloid in the presence of testosterone. beta -Amyloid neurotoxicity was significantly reduced by testosterone via a rapid, estrogen-independent mechanism. These data may provide additional insight into the treatment of age-related neurodegenerative disorders. (C) 2001 Published by Elsevier Science BY.

引用

页码：160 / 165

页数：6

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