Sphingosine-1-phosphate (S1P) is a biologically active metabolite of plasma-membrane sphingolipids that is essential for immune-cell trafficking. Its concentration is increased in many inflammatory conditions, such as asthma and autoimmunity. Much of the immune function of S1P results from the engagement of a family of G-protein-coupled receptors (S1PR1-S1PR5). Recent findings on the role of S1P in immunosurveillance, the discovery of regulatory mechanisms in S1P-mediated immune-cell trafficking and new advances in understanding the mechanism by which S1P affects immune-cell function indicate that the alliance between S1P and its receptors has a fundamental role in immunity.
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NIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USANIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USA
Allende, Maria L.
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Zhou, Dapeng
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Univ Texas Houston, MD Anderson Canc Ctr, Dept Melanoma Med Oncol, Houston, TX 77030 USANIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USA
Zhou, Dapeng
;
Kalkofen, Danielle N.
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NIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USANIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USA
Kalkofen, Danielle N.
;
Benhamed, Sonia
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NIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USANIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USA
Benhamed, Sonia
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Tuymetova, Galina
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NIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USANIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USA
Tuymetova, Galina
;
Borowski, Christine
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Univ Chicago, Comm Immunol, Chicago, IL 60637 USA
Howard Hughes Med Inst, Chicago, IL USANIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USA
Borowski, Christine
;
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Bendelac, Albert
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Proia, Richard L.
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NIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USANIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USA
机构:
NIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USANIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USA
Allende, Maria L.
;
Zhou, Dapeng
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h-index: 0
机构:
Univ Texas Houston, MD Anderson Canc Ctr, Dept Melanoma Med Oncol, Houston, TX 77030 USANIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USA
Zhou, Dapeng
;
Kalkofen, Danielle N.
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h-index: 0
机构:
NIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USANIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USA
Kalkofen, Danielle N.
;
Benhamed, Sonia
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h-index: 0
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NIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USANIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USA
Benhamed, Sonia
;
Tuymetova, Galina
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h-index: 0
机构:
NIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USANIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USA
Tuymetova, Galina
;
Borowski, Christine
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Comm Immunol, Chicago, IL 60637 USA
Howard Hughes Med Inst, Chicago, IL USANIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USA
Borowski, Christine
;
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h-index:
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Bendelac, Albert
;
Proia, Richard L.
论文数: 0引用数: 0
h-index: 0
机构:
NIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USANIDDK, Natl Inst Hlth, Genet Dev & Dis Branch, Bethesda, MD 20892 USA