The alliance of sphingosine-1-phosphate and its receptors in immunity

被引:535
作者
Rivera, Juan [1 ]
Proia, Richard L. [2 ]
Olivera, Ana [1 ]
机构
[1] NIAMSD, Lab Immune Cell Signaling, Bethesda, MD 20892 USA
[2] NIDDK, Genet Dev & Dis Branch, NIH, Bethesda, MD 20892 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nri2400
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Sphingosine-1-phosphate (S1P) is a biologically active metabolite of plasma-membrane sphingolipids that is essential for immune-cell trafficking. Its concentration is increased in many inflammatory conditions, such as asthma and autoimmunity. Much of the immune function of S1P results from the engagement of a family of G-protein-coupled receptors (S1PR1-S1PR5). Recent findings on the role of S1P in immunosurveillance, the discovery of regulatory mechanisms in S1P-mediated immune-cell trafficking and new advances in understanding the mechanism by which S1P affects immune-cell function indicate that the alliance between S1P and its receptors has a fundamental role in immunity.
引用
收藏
页码:753 / 763
页数:11
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