The alliance of sphingosine-1-phosphate and its receptors in immunity

被引：540

作者：

Rivera, Juan ^{[1
]}

Proia, Richard L. ^{[2
]}

Olivera, Ana ^{[1
]}

机构：

[1] NIAMSD, Lab Immune Cell Signaling, Bethesda, MD 20892 USA

[2] NIDDK, Genet Dev & Dis Branch, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri2400

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sphingosine-1-phosphate (S1P) is a biologically active metabolite of plasma-membrane sphingolipids that is essential for immune-cell trafficking. Its concentration is increased in many inflammatory conditions, such as asthma and autoimmunity. Much of the immune function of S1P results from the engagement of a family of G-protein-coupled receptors (S1PR1-S1PR5). Recent findings on the role of S1P in immunosurveillance, the discovery of regulatory mechanisms in S1P-mediated immune-cell trafficking and new advances in understanding the mechanism by which S1P affects immune-cell function indicate that the alliance between S1P and its receptors has a fundamental role in immunity.

引用

页码：753 / 763

页数：11

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