Direct analysis of fluoxetine and norfluoxetine in plasma by gas chromatography with nitrogen-phosphorus detection

被引：40

作者：

Fontanille, P ^{[1
]}

Jourdil, N ^{[1
]}

Villier, C ^{[1
]}

Bessard, G ^{[1
]}

机构：

[1] CHU GRENOBLE,PHARMACOL LAB,F-38043 GRENOBLE 9,FRANCE

来源：

JOURNAL OF CHROMATOGRAPHY B | 1997年 / 692卷 / 02期

关键词：

fluoxetine; norfluoxetine;

D O I：

10.1016/S0378-4347(96)00486-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

quantitative method for the simultaneous GC resolution and detection of fluoxetine and his metabolite norfluoxetine in human plasma was developed. The procedure required 1.0 ml of plasma, extraction with a mixed organic solvent and injection into a capillary gas chromatograph with an OV-1 fused-silica column coupled to a nitrogen-phosphorus detector. The calibration curves were linear over the range 5-3000 ng/ml. The detection limits were 0.3 and 2 ng/ml for fluoxetine and norfluoxetine, respectively. The assay is suitable for routine analysis.

引用

页码：337 / 343

页数：7

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