Low density lipoprotein apheresis therapy for steroid-resistant nephrotic syndrome

被引：46

作者：

Muso, E

Mune, M

Fujii, Y

Imai, E

Ueda, N

Hatta, K

Imada, A

Miki, S

Kuwahara, T

Takamitsu, Y

Takemura, T

Tsubakihara, Y

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068397, Japan

[2] Wakayama Med Coll, Wakayama 640, Japan

[3] Nara Med Univ, Nara, Japan

[4] Tenri Hosp, Nara, Japan

[5] Osaka Univ, Fac Med, Suita, Osaka 565, Japan

[6] Kinki Univ, Sch Med, Higashiosaka, Osaka 577, Japan

[7] Osaka Saiseikai Nakatsu Hosp, Osaka, Japan

[8] Osaka Prefecture Hosp, Osaka, Japan

[9] Hyogo Coll Med, Nishinomiya, Hyogo, Japan

[10] Takasago City Hosp, Takasago, Hyogo, Japan

来源：

KIDNEY INTERNATIONAL | 1999年 / 56卷

关键词：

thromboxane B-2; progressive renal disease; tubulointerstitial injury; focal segmental glomerulosclerosis; minimal change nephrotic syndrome;

D O I：

10.1046/j.1523-1755.1999.07130.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background. The pathogenic role of hyperlipidemia in longstanding nephrotic syndrome (NS) is known to be responsible for both the progression of glomerulosclerosis and tubulointerstitial injury, especially in focal segmental glomerulosclerosis (FGS). Methods. Aggressive lipid lowering treatment by low density lipoprotein (LDL) apheresis (LDL-A) using a dextran sulfate cellulose column to treat patients with steroid-resistant or frequently recurrent severe NS was performed first without fixing the protocol in eight patients with FGS and one with minimal change nephrotic syndrome (MCNS). The period of NS before LDL-X, number and average intervals of LDL-A until the end of the therapy, and the prognosis were investigated. Next, a multicenter study with a fixed protocol of LDL-A treatment was designed in combination with steroid therapy for treatment twice a week for three weeks and weekly for six weeks. and was performed in 17 patients with FGS. The effects on the state of NS in addition to the change of urinary eicosanoid metabolites and remission rates were evaluated. Results. In the preliminary study, along with a rapid improvement of hyperlipidemia, a high incidence of remission was achieved by LDL-A performed at relatively short intervals. In the multicenter study with a fixed protocol. there was a significant decrease of urinary protein (P < 0.001) and increase of serum albumin (P < 0.02) as well as a decrease of thromboxane B-2 (TxB(2)) excretion (P < 0.05) after the treatment. Urinary excretion of TXB2 was significantly reduced after LDL-A (P < 0.05). The rate of entering into complete or incomplete remission was 71% with a relatively short duration of nephrotic-range proteinuria using the LDL-A therapy in comparison with steroid therapy alone. Conclusion. The rapid improvement of hypercholesterolemia with LDL-A treatment may provide a new approach for a high rate of improvement in the degree of NS in steroid-resistant NS of FGS and MCNS.

引用

页码：S122 / S125

页数：4

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