Molecular mechanisms of probiotic action: a proteomic perspective

被引：48

作者：

Siciliano, Rosa Anna ^{[1
]}

Mazzeo, Maria Fiorella ^{[1
]}

机构：

[1] CNR, Ctr Spettrometria Massa Prote & Biomol, Ist Sci Alimentaz, Avellino, Italy

来源：

CURRENT OPINION IN MICROBIOLOGY | 2012年 / 15卷 / 03期

关键词：

ANIMALIS SUBSP LACTIS; BACTERIUM LACTOBACILLUS-REUTERI; BIFIDOBACTERIUM-LONGUM; PROTEIN EXPRESSION; ACID STRESS; BILE-SALTS; EXPORTED PROTEINS; HUMAN PLASMINOGEN; ACIDOPHILUS NCFM; RHAMNOSUS GG;

D O I：

10.1016/j.mib.2012.03.006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Probiotics are living microorganisms that confer beneficial effects to human health when supplied in adequate amounts, by promoting digestion and uptake of dietary nutrients, strengthening intestinal barrier function, modulating immune response and enhancing antagonism towards pathogens. The purpose of the present article is to focus on microbial proteomics, pointing out its usefulness in the investigation of molecular mechanisms underlying probiotic effects. It deals, in particular, with molecular strategies responsible for adaptation to the harsh physical chemical environment of the gastro-intestinal tract, bacterial adhesion to host epithelial cells and intestinal mucosa and probiotic immunomodulatory properties, as analyzed by proteomics in the past few years.

引用

页码：390 / 396

页数：7

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