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Mononuclear and polymorphonuclear leukocyte dispositions of clarithromycin and azithromycin in AIDS patients requiring Mycobacterium avium complex prophylaxis

被引：6
作者：
Bui, KQ
McNabb, J
Li, CH
Nightingale, CH
Nicolau, DP
机构：
[1] Hartford Hosp, Dept Res Adm, Hartford, CT 06102 USA
[2] Hartford Hosp, Dept Pharm Res, Hartford, CT 06102 USA
[3] Hartford Hosp, Dept Med, Div Infect Dis, Hartford, CT 06102 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 09期
关键词：
D O I：
10.1128/AAC.43.9.2302
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The intracellular dispositions of clarithromycin and azithromycin in AIDS patients requiring Mycobacterium avium complex (MAC) prophylaxis were studied. The dispositions of both drugs in mononuclear and polymorphonuclear leukocytes were markedly different. Our data support the proven efficacy of these agents for ILIAC prophylaxis since clarithromycin and azithromycin displayed sustained intracellular concentrations which exceeded their MICs for MAC throughout the dosing periods.
引用
收藏
页码：2302 / 2304
页数：3
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