Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus

被引：60

作者：

Li, HB

Zhou, CX

Pan, YX

Gao, XZ

Wu, XM

Bai, H

Zhou, LF

Chen, Z

Zhang, SL

Shi, SY

Luo, JL

Xu, JH

Chen, LR

Zheng, XX

Zhao, Y ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Dept Tradit Chinese Med & Nat Drug Res, Hangzhou 310031, Peoples R China

[2] Zhejiang Hisun Nat Pharmaceut R&D Co Ltd, Hangzhou, Peoples R China

[3] Zhejiang Univ, Sch Med, Inst Infect Dis, Hosp 1, Hangzhou, Peoples R China

[4] Zhejiang Univ, Coll Biomed Engn & Instrument Sci, Dept Biomed Engn, Hangzhou, Peoples R China

来源：

PLANTA MEDICA | 2005年 / 71卷 / 12期

关键词：

anti-virus; Ranunculus sieboldii; Ranunculus sceleratus; Ranunculaceae; hepatitis B virus; Herpes simplex virus type 1; flavone glycosides;

D O I：

10.1055/s-2005-873169

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Nineteen compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus were tested for inhibitory effects on hepatitis B virus (HBV) and Herpes simplex virus type-1 (HSV-1). The results showed that apigenin 4prime-O-alpha-rhamnopyranoside (1), apigenin 7-O-beta-glucopyranosyl-4prime-O-alpha-rhamnopyranoside (4), tricin 7-O-beta-glucopyranoside (5), tricin (12), and isoscopoletin (18) possessed inhibitory activity against HBV replication. Protocatechuyl aldehyde (19) exhibited an inhibiting activity on HSV-1 replication. It is therefore suggested that further investigations on these bioactive compounds might be needed to discover anddevelop new antiviral agents.

引用

页码：1128 / 1133

页数：6

共 26 条

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