Positive prognostic impact of miR-210 in non-small cell lung cancer

被引：86

作者：

Eilertsen, Marte ^{[1
]}

Andersen, Sigve ^{[1
,2
]}

Al-Saad, Samer ^{[3
,4
]}

Richardsen, Elin ^{[3
,4
]}

Stenvold, Helge ^{[1
,2
]}

Hald, Sigurd M. ^{[1
]}

Al-Shibli, Khalid ^{[3
,5
]}

Donnem, Tom ^{[1
,2
]}

Busund, Lill-Tove ^{[3
,4
]}

Bremnes, Roy M. ^{[1
,2
]}

机构：

[1] Univ Tromso, Dept Clin Med, NO-9037 Tromso, Norway

[2] Univ Hosp North Norway, Dept Oncol, Tromso, Norway

[3] Univ Tromso, Dept Med Biol, NO-9037 Tromso, Norway

[4] Univ Hosp North Norway, Dept Clin Pathol, Tromso, Norway

[5] Nordland Cent Hosp, Dept Pathol, Bodo, Norway

来源：

LUNG CANCER | 2014年 / 83卷 / 02期

关键词：

NSCLC; Prognosis; miR-210; Tumor stromal cells; Cancer cells; Biomarker; GENE-EXPRESSION; SQUAMOUS-CELL; HYPOXIA; TUMOR; MICRORNAS; MARKER; GROWTH; HSA-MIR-210; DIAGNOSIS; SPUTUM;

D O I：

10.1016/j.lungcan.2013.11.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Objectives: miR-210 is an important regulator of the cellular response to hypoxia. Therefore, we aimed to explore the prognostic significance of miR-210 in non-small cell lung cancer (NSCLC) patients with stage I-IIIA disease. Materials and methods: In addition to clinicopathological and demograpic information, tumor tissues were collected and tissue micro arrays (TMAs) were constructed from 335 patients with stage I-IIIA NSCLC. Expression of miR-210 in cancer cells and stromal cells of the tumor was assessed by in situ hybridization. Results: In univariate analyses, high cancer cell (p = 0.039) and high stromal cell expression (p = 0.008) of miR-210 were both significantly associated with an improved disease-spesific survival (DSS). High co-expression of miR-210 in cancer and stromal cells was also a positive prognostic factor for DSS (p = 0.010). In multivariate analysis, miR-210 in stromal cells (p = 0.011), and miR-210 co-expressed in cancer and stromal cells was an independent prognosticator for DSS (p = 0.011). Conclusions: We show that miR-210 in stromal cells, and co-expressed in cancer cells and stromal cells mediates an independent prognostic impact. It is a candidate marker for prognostic stratification in NSCLC. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：272 / 278

页数：7

共 44 条

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Overexpression of the HIF Hydroxylases PHD1, PHD2, PHD3 and FIH Are Individually and Collectively Unfavorable Prognosticators for NSCLC Survival [J].