Are the reactive oxygen-derived species (ROS) interactive properties of the many therapeutic drugs from various categories pertinent to their beneficial effects?

被引：8

作者：

Cash, CD

机构：

[1] Centre de Neurochimie, 67084 Strasbourg

来源：

GENERAL PHARMACOLOGY | 1997年 / 28卷 / 02期

关键词：

antioxidants; free radicals; reactive oxygen species; therapeutic drugs;

D O I：

10.1016/S0306-3623(96)00285-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Many pathologic states are known to involve the generation of reactive oxygen species, (ROS). It is not known at present to what extent these phenomena are due to ROS formation, or if their formation is a result of the disease. Many therapeutic drugs either scavenge ROS or inhibit their formation. The purpose of this review is to match the drugs used for certain diseases with their anti-ROS actions. This attempted correlation is made to try to give an answer to the title question. Copyright (C) 1997 Elsevier Science Inc.

引用

页码：169 / 175

页数：7

共 114 条

[11] LIPID PEROXIDATION-INDUCED INHIBITION OF GAMMA-AMINOBUTYRIC ACID UPTAKE IN RAT-BRAIN SYNAPTOSOMES - PROTECTION BY GLUCOCORTICOIDS [J].