Merging photoredox catalysis with organocatalysis: The direct asymmetric alkylation of aldehydes

被引：1973

作者：

Nicewicz, David A. ^{[1
]}

MacMillan, David W. C. ^{[1
]}

机构：

[1] Princeton Univ, Dept Chem, Merck Ctr Catalysis, Princeton, NJ 08544 USA

来源：

SCIENCE | 2008年 / 322卷 / 5898期

关键词：

D O I：

10.1126/science.1161976

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Photoredox catalysis and organocatalysis represent two powerful fields of molecule activation that have found widespread application in the areas of inorganic and organic chemistry, respectively. We merged these two catalysis fields to solve problems in asymmetric chemical synthesis. Specifically, the enantioselective intermolecular alpha-alkylation of aldehydes has been accomplished using an interwoven activation pathway that combines both the photoredox catalyst Ru(bpy)(3)Cl-2 (where bpy is 2,2 '-bipyridine) and an imidazolidinone organocatalyst. This broadly applicable, yet previously elusive, alkylation reaction is now highly enantioselective and operationally trivial.

引用

页码：77 / 80

页数：4

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