Electronic-Topological Study of Structurally Diverse Cyclooxygenase-2 Inhibitors

被引：10

作者：

Dimoglo, A. ^{[1
]}

Sim, E. ^{[1
]}

Shvets, N. ^{[1
]}

Ahsen, V. ^{[1
]}

机构：

[1] Gebze Inst Technol, TR-41400 Gebze, Turkey

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2003年 / 3卷 / 04期

关键词：

COX-2; NSAIDs; Structure-Activity Relationships (SAR);

D O I：

10.2174/1389557033488060

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A large series of cyclooxygenase-2 (COX-2) inhibitors with diverse skeletons were investigated by means of the Electronic-Topological Method. A system for the COX-2 inhibitor activity prognostication was built with 6 pharmacophores and 6 anti-pharmacophores. The forecasting ability of the system was also tested on different structures, which differ from those that characterize the series studied.

引用

页码：281 / 294

页数：14

共 27 条

[1]

Carter J.S., 2000, US Patent, Patent No. [6 034 256, 6034256]

[2] MECHANISM OF SELECTIVE-INHIBITION OF THE INDUCIBLE ISOFORM OF PROSTAGLANDIN G/H SYNTHASE [J].