Precursor-directed biosynthesis of beauvericin analogs by the insect pathogenic fungus Paecilomyces tenuipes BCC 1614

被引：85

作者：

Nilanonta, C

Isaka, M

Kittakoop, P

Trakulnaleamsai, S

Tanticharoen, M

Thebtaranonth, Y

机构：

[1] Natl Ctr Genet Engn & Biotechnol, BIOTEC, Nat Sci & Technol Dev Agcy, Bangkok 10400, Thailand

[2] Mahidol Univ, Dept Chem, Bangkok 10400, Thailand

来源：

TETRAHEDRON | 2002年 / 58卷 / 17期

关键词：

beauvericin; cyclodepsipeptides; precursor-directed biosynthesis; antiplasmodial activity; antimycobacterial activity;

D O I：

10.1016/S0040-4020(02)00294-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Precursor-directed biosynthesis of beauvericin analogs, cyclohexadepsipeptide antibiotics, was investigated using the insect pathogenic fungus Paecilomyces tenuipes BCC 1614. Feeding L-isoleucine or D-alloisoleucine in liquid medium led to the enhanced production of beauvericin A and beauvericin B together with beauvericin and a missing analog, beauvericin C. Feeding experiments with D-isoleucine or L-alloisoleucine resulted in the production of diastereomers of beauvericins A, B and C, named allobeauvericins A, B and C, respectively. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：3355 / 3360

页数：6

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