Inhibition of herpes simplex virus infection by oligomeric stilbenoids through ROS generation

被引：51

作者：

Chen, Xiaoqing ^{[1
,2
,3
]}

Qiao, Haishi ^{[1
,2
,3
]}

Liu, Taixiang ^{[1
,2
,3
]}

Yang, Ziying ^{[1
]}

Xu, Lanfang ^{[1
]}

Xu, Yunxia ^{[1
]}

Ge, Hui Ming ^{[1
]}

Tan, Ren-Xiang ^{[1
]}

Li, Erguang ^{[1
,2
,3
]}

机构：

[1] Nanjing Univ, Sch Med, State Key Lab Pharmaceut Biotechnol, Coll Life Sci, Nanjing 210093, Peoples R China

[2] Nanjing Univ, Sch Med, Nanjing 210093, Jiangsu, Peoples R China

[3] Jiangsu Lab Mol Med, Nanjing 210093, Jiangsu, Peoples R China

来源：

ANTIVIRAL RESEARCH | 2012年 / 95卷 / 01期

关键词：

Herpes simplex virus; Resveratrol; Stilbenoid; Reactive oxygen species; KAPPA-B; RESVERATROL; P53; ANTIOXIDANT; ACTIVATION; TYPE-1; OLIGOSTILBENOIDS; PEROXIDATION; RECOGNITION; MECHANISMS;

D O I：

10.1016/j.antiviral.2012.05.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Stilbenoids including resveratrol contain the basic structural unit of 1,2-diphenylethylene. Naturally occurring stilbenoids have broad structural features due to oligomerization and modifications and some have demonstrated potent biological activities. In an effort to identify bioactive stilbenoids, we screened a group of dimeric and oligomeric stilbenoids against HSV-1 and HSV-2 infection. Several trimeric and tetrameric derivatives showed anti-herpetic activity at single digit micromolar concentrations. HSV-1 and HSV-2 replication requires for NF-kappa B and MAPK activation. The compounds showed no inhibitory activity against NF-kappa B and Erk/MAPK activation, instead those compounds promoted rapid and transient release of reactive oxygen species (ROS). Addition of N-acetylcysteine (NAC), a scavenger of ROS, reversed the inhibitory effect of those compounds against HSV replication. In addition to the identification of resveratrol derivatives with potent anti-HSV activity, our results uncover a mechanism of polyphenol-mediated anti-HSV response, linking anti-herpetic activity of oligomeric stilbenoids to innate immunity. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：30 / 36

页数：7

共 52 条

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