Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate

被引：382

作者：

Waung, Maggie W. ^{[1
]}

Pfeiffer, Brad E. ^{[1
]}

Nosyreva, Elena D. ^{[1
]}

Ronesi, Jennifer A. ^{[1
]}

Huber, Kimberly M. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Neurosci, Dallas, TX 75390 USA

来源：

NEURON | 2008年 / 59卷 / 01期

关键词：

D O I：

10.1016/j.neuron.2008.05.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Salient stimuli that modify behavior induce transcription of activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) and transport Arc mRNA into dendrites, suggesting that local Arc translation mediates synaptic plasticity that encodes such stimuli. Here, we demonstrate that long-term synaptic depression (LTD) in hippocampal neurons induced by group 1 metabotropic glutamate receptors (mGluRs) relies on rapid translation of Arc. mGluR-LTD induction causes long-term increases in AMPA receptor endocytosis rate and dendritic synthesis of Arc, a component of the AMPAR endocytosis machinery. Knockdown of Arc prevents mGluRs from triggering AMPAR endocytosis or LTD, and acute blockade of new Arc synthesis with antisense oligonucleotides blocks mGluR-LTD and AMPAR trafficking. In contrast, LTD induced by NMDA receptors does not persistently alter AMPAR endocytosis rate, induce Arc synthesis, or require Arc protein. These data demonstrate a role for local Arc synthesis specifically in mGluR-LTD and suggest that mGluR-LTD may be one consequence of Arc mRNA induction during experience.

引用

页码：84 / 97

页数：14

共 57 条

[11] Topography of Arc/Arg3.1 mRNA expression in the dorsal and ventral hippocampus induced by recent and remote spatial memory recall: Dissociation of CA3 and CA1 activation [J].

Gusev, PA ;

Cui, C ;

Alkon, DL ;

Gubin, AN .

JOURNAL OF NEUROSCIENCE, 2005, 25 (41) :9384-9397

[12] Recent behavioral history modifies coupling between cell activity and Arc gene transcription in hippocampal CA1 neurons [J].

Guzowski, JF ;

Miyashita, T ;

Chawla, MK ;

Sanderson, J ;

Maes, LI ;

Houston, FP ;

Lipa, P ;

McNaughton, BL ;

Worley, PF ;

Barnes, CA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (04) :1077-1082

[13] Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles [J].

Guzowski, JF ;

McNaughton, BL ;

Barnes, CA ;

Worley, PF .

NATURE NEUROSCIENCE, 1999, 2 (12) :1120-1124

[14]

Guzowski JF, 2000, J NEUROSCI, V20, P3993

[15] Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depression [J].

Hou, Lingfei ;

Antion, Marcia D. ;

Hu, Daoying ;

Spencer, Corinne M. ;

Paylor, Richard ;

Klann, Eric .

NEURON, 2006, 51 (04) :441-454

[16] Altered synaptic plasticity in a mouse model of fragile X mental retardation [J].

Huber, KM ;

Gallagher, SM ;

Warren, ST ;

Bear, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (11) :7746-7750

[17] Chemical induction of mGluR5-and protein synthesis-dependent long-term depression in hippocampal area CA1 [J].

Huber, KM ;

Roder, JC ;

Bear, MF .

JOURNAL OF NEUROPHYSIOLOGY, 2001, 86 (01) :321-325

[18] Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression [J].

Huber, KM ;

Kayser, MS ;

Bear, MF .

SCIENCE, 2000, 288 (5469) :1254-1256

[19]

Iacoangeli A, 2008, P NATL ACAD SCI USA, V105, P734, DOI [10.1073/pnas.0710991105, 10.1073/pnas.0803737105]

[20] Translational regulatory mechanisms in persistent forms of synaptic plasticity [J].

Kelleher, RJ ;

Govindarajan, A ;

Tonegawa, S .

NEURON, 2004, 44 (01) :59-73

← 1 2 3 4 5 6 →