T cell metabolism drives immunity

被引：846

作者：

Buck, Michael D. ^{[1
]}

O'Sullivan, David ^{[1
]}

Pearce, Erika L. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2015年 / 212卷 / 09期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

FATTY-ACID-METABOLISM; BETA-SELECTION CHECKPOINT; ACTIVATED PROTEIN-KINASE; ESSENTIAL AMINO-ACIDS; ATP CITRATE LYASE; REGULATORY T; DENDRITIC CELLS; RETINOIC-ACID; PHOSPHATIDYLINOSITOL; 3-KINASE; EFFECTOR RESPONSES;

D O I：

10.1084/jem.20151159

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lymphocytes must adapt to a wide array of environmental stressors as part of their normal development, during which they undergo a dramatic metabolic remodeling process. Research in this area has yielded surprising findings on the roles of diverse metabolic pathways and metabolites, which have been found to regulate lymphocyte signaling and influence differentiation, function and fate. In this review, we integrate the latest findings in the field to provide an up-to-date resource on lymphocyte metabolism.

引用

页码：1345 / 1360

页数：16

共 215 条

[51] The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery [J].

Ernst, B ;

Lee, DS ;

Chang, JM ;

Sprent, J ;

Surh, CD .

IMMUNITY, 1999, 11 (02) :173-181

[52] Quantitative flux analysis reveals folate-dependent NADPH production [J].

Fan, Jing ;

Ye, Jiangbin ;

Kamphorst, Jurre J. ;

Shlomi, Tomer ;

Thompson, Craig B. ;

Rabinowitz, Joshua D. .

NATURE, 2014, 510 (7504) :298-+

[53] Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters [J].

Feuerer, Markus ;

Herrero, Laura ;

Cipolletta, Daniela ;

Naaz, Afia ;

Wong, Jamie ;

Nayer, Ali ;

Lee, Jongsoon ;

Goldfine, Allison B. ;

Benoist, Christophe ;

Shoelson, Steven ;

Mathis, Diane .

NATURE MEDICINE, 2009, 15 (08) :930-U137

[54] Cutting edge:: Changes in histone acetylation at the IL-4 and IFN-γ loci accompany Th1/Th2 differentiation [J].

Fields, PE ;

Kim, ST ;

Flavell, RA .

JOURNAL OF IMMUNOLOGY, 2002, 169 (02) :647-650

[55] PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells [J].

Finlay, David K. ;

Rosenzweig, Ella ;

Sinclair, Linda V. ;

Feijoo-Carnero, Carmen ;

Hukelmann, Jens L. ;

Rolf, Julia ;

Panteleyev, Andrey A. ;

Okkenhaug, Klaus ;

Cantrell, Doreen A. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2012, 209 (13) :2441-2453

[56] L-Arginine Depletion Blunts Antitumor T-cell Responses by Inducing Myeloid-Derived Suppressor Cells [J].

Fletcher, Matthew ;

Ramirez, Maria E. ;

Sierra, Rosa A. ;

Raber, Patrick ;

Thevenot, Paul ;

Al-Khami, Amir A. ;

Sanchez-Pino, Dulfary ;

Hernandez, Claudia ;

Wyczechowska, Dorota D. ;

Ochoa, Augusto C. ;

Rodriguez, Paulo C. .

CANCER RESEARCH, 2015, 75 (02) :275-283

[57] Fuel feeds function: Energy metabolism and the T-cell response [J].

Fox, CJ ;

Hammerman, PS ;

Thompson, CB .

NATURE REVIEWS IMMUNOLOGY, 2005, 5 (11) :844-852

[58] Preexisting High Frequencies of Memory CD8+ T Cells Favor Rapid Memory Differentiation and Preservation of Proliferative Potential upon Boosting [J].

Fraser, Kathryn A. ;

Schenkel, Jason M. ;

Jameson, Stephen C. ;

Vezys, Vaiva ;

Masopust, David .

IMMUNITY, 2013, 39 (01) :171-183

[59] The CD28 signaling pathway regulates glucose metabolism [J].

Frauwirth, KA ;

Riley, JL ;

Harris, MH ;

Parry, RV ;

Rathmell, JC ;

Plas, DR ;

Elstrom, RL ;

June, CH ;

Thompson, CB .

IMMUNITY, 2002, 16 (06) :769-777

[60] Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells [J].

Furusawa, Yukihiro ;

Obata, Yuuki ;

Fukuda, Shinji ;

Endo, Takaho A. ;

Nakato, Gaku ;

Takahashi, Daisuke ;

Nakanishi, Yumiko ;

Uetake, Chikako ;

Kato, Keiko ;

Kato, Tamotsu ;

Takahashi, Masumi ;

Fukuda, Noriko N. ;

Murakami, Shinnosuke ;

Miyauchi, Eiji ;

Hino, Shingo ;

Atarashi, Koji ;

Onawa, Satoshi ;

Fujimura, Yumiko ;

Lockett, Trevor ;

Clarke, Julie M. ;

Topping, David L. ;

Tomita, Masaru ;

Hori, Shohei ;

Ohara, Osamu ;

Morita, Tatsuya ;

Koseki, Haruhiko ;

Kikuchi, Jun ;

Honda, Kenya ;

Hase, Koji ;

Ohno, Hiroshi .

NATURE, 2013, 504 (7480) :446-+

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