Neuroprotective utility and neurotrophic action of neurturin in postnatal motor neurons: Comparison with GDNF and persephin

被引：44

作者：

Bilak, MM ^{[1
]}

Shifrin, DA ^{[1
]}

Corse, AM ^{[1
]}

Bilak, SR ^{[1
]}

Kuncl, RW ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 1999年 / 13卷 / 05期

关键词：

D O I：

10.1006/mcne.1999.0756

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurturin and persephin are recently discovered homologs of glial cell line-derived neurotrophic factor (GDNF). Here, we report that neurturin, like GDNF, increases the choline acetyltransferase activity of normal postnatal motor neurons, induces neurite outgrowth in spinal cord, and potently protects motor neurons from chronic glutamate-mediated degeneration. Persephin, in contrast, does not appear to have neurotrophic or neurite-promoting effects on mature motor neurons and may instead worsen the glutamate injury of motor neurons. This pattern in the TGF-beta family suggests certain receptor specificities, requiring at least the Ret/GFR alpha-1 receptor complex. The results predict potential benefit of neurturin, but not persephin, in the treatment of motor neuron disorders and spinal cord diseases.

引用

页码：326 / 336

页数：11