Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo

被引：271

作者：

Garvin, S

Öllinger, K

Dabrosin, C ^{[1
]}

机构：

[1] Linkoping Univ Hosp, Fac Hlth Sci, Div Gynecol Oncol, SE-58185 Linkoping, Sweden

[2] Linkoping Univ Hosp, Fac Hlth Sci, Div Pathol 2, SE-58185 Linkoping, Sweden

来源：

CANCER LETTERS | 2006年 / 231卷 / 01期

关键词：

angiogenesis; apoptosis; MDA-MB-231; vascular endothelial growth factor; VEGF;

D O I：

10.1016/j.canlet.2005.01.031

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Resveratrol, a polyphenol found in grapes and wine, is considered a potential cancer chemopreventive agent. Resveratrol has been shown to induce transcription via both ER alpha and ER beta. We observed significantly lower tumor growth, decreased angiogenesis, and increased apoptotic index in ER alpha- ER beta+ MDA-MB-231 tumors in resveratrol-treated nude mice compared with controls. In vitro we found a significant increase in apoptosis in resveratrol-treated MDA-MB-231 cells in addition to significantly reduced extracellular levels of VEGF. This study supports the potential use of resveratrol as a chemotherapeutic agent in breast cancers. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：113 / 122

页数：10

共 54 条

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[12] Resveratrol acts as a mixed agonist/antagonist for estrogen receptors α and β [J].