Cloning and expression of the cDNA encoding rat tissue inhibitor of metalloproteinase 3 (TIMP-3)

被引：25

作者：

Wu, IM

Moses, MA

机构：

[1] CHILDRENS HOSP,SURG RES LAB,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,DEPT SURG,BOSTON,MA 02115

来源：

GENE | 1996年 / 168卷 / 02期

关键词：

extracellular matrix; matrix-bound protein; human TIMP; glycoprotein; polymerase chain reaction; cDNA;

D O I：

10.1016/0378-1119(95)00783-0

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have cloned the cDNA encoding the rat tissue inhibitor of metalloproteinase 3 (TIMP-3) by a PCR cloning method. Sequence analysis reveals an open reading frame containing 211 amino acids that show 99% identity to mouse TIMP-3 and 95% identity to human TIMP-3, respectively. High-level expression of TIMP-3 was detected in rat kidney, lungs and heart.

引用

页码：243 / 246

页数：4

共 20 条

[1] GENE ENCODING A NOVEL MURINE TISSUE INHIBITOR OF METALLOPROTEINASES (TIMP), TIMP-3, IS EXPRESSED IN DEVELOPING MOUSE EPITHELIA, CARTILAGE, AND MUSCLE, AND IS LOCATED ON MOUSE CHROMOSOME-10 [J].