Evaluation of Alginate-Chitosan Bioadhesive Beads as a Drug Delivery System for the Controlled Release of Theophylline

被引：38

作者：

Elzatahry, A. A. ^{[1
]}

Eldin, M. S. Mohy ^{[1
]}

Soliman, E. A. ^{[1
]}

Hassan, E. A. ^{[2
]}

机构：

[1] Adv Technol & New Mat Res Inst, Lab Drug Delivery Syst, Polymer Mat Res Dept, Alexandria, Egypt

[2] Al Azhar Univ, Fac Sci, Dept Chem, Cairo, Egypt

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2009年 / 111卷 / 05期

关键词：

biopolymers; drug delivery systems; hydrogels; microencapsulation; polysaccharides; POLYELECTROLYTE COMPLEXES; SODIUM ALGINATE; PROTEIN DRUGS; MICROPARTICLES; MICROCAPSULES; MICROSPHERES; DERIVATIVES; MEMBRANES; BEHAVIOR; GELATION;

D O I：

10.1002/app.29221

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This study describes the preparation of mucoadhesive alginate-chitosan beads containing theophylline intended for colon-specific delivery. The calcium alginate beads were coated with chitosan by the ionotropic hydrogelation method with a polyelectrolyte complex reaction between two oppositely charged polyions. The release profiles of theophylline from the beads were determined by ultraviolet-visible absorption measurement at 272 nm. Scanning electron microscopy was used for morphology observation. The in vitro mucoadhesive tests for particles were carried out with the freshly excised jejunum of Sprague-Dawley rats. The bead particles, which ranged in size from 200 to 400 mu m, exhibited excellent mucoadhesive properties. The results showed that the formulated coated beads succeeded in controlling the release of theophylline over a 24-h period. In conclusion, the release of theophylline was found to be dependent on the composition of the beads, the component polymer and its possible interactions, and the bioadhesiveness. (c) 2008 Wiley Periodicals, Inc. J Appl Polym Sci 111: 2452-2459, 2009

引用

页码：2452 / 2459

页数：8

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