Mixed lineage kinase activity of indolocarbazole analogues

被引：90

作者：

Murakata, C

Kaneko, M

Gessner, G

Angeles, TS

Ator, MA

O'Kane, TM

McKenna, BAW

Thomas, BA

Mathiasen, JR

Saporito, MS

Bozyczko-Coyne, D

Hudkins, RL

机构：

[1] Cephalon Inc, Dept Med Chem, W Chester, PA 19380 USA

[2] Cephalon Inc, Dept Biochem, W Chester, PA 19380 USA

[3] Cephalon Inc, Dept Neurobiol, W Chester, PA 19380 USA

[4] Kyowa Hakko Kogyo Co Ltd, Tokyo, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)00690-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The MLKI-3 activity for a series of analogues of the indolocarbazole K-252a is reported. Addition of 3,9-bis-alkylthiomethyl groups to K-252a results in potent and selective MLK inhibitors. The in vitro and in vivo survival promoting activity of bis-isopropylthiomethyl-K-252a (16, CEP-11004/KT-8138)is reported. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：147 / 150

页数：4

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