Mechanisms for inducing nasal mucosal tolerance in experimental autoimmune uveoretinitis

被引：7

作者：

Calder, CJ

Nicholson, LB

Dick, AD ^{[1
]}

机构：

[1] Univ Bristol, Dept Clin Sci, Bristol BS8 1TH, Avon, England

[2] Univ Bristol, Dept Pathol & Microbiol, Bristol BS8 1TH, Avon, England

来源：

METHODS | 2006年 / 38卷 / 02期

关键词：

respiratory tract dendritic cells; flow cytometry; tolerance; autoimmunity;

D O I：

10.1016/j.ymeth.2005.09.008

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Delivering soluble (auto) antigenic peptides via the naso-respiratory route induces tolerance to that peptide and suppression of experimental models of autoimmune disease. In the normal lung, respiratory tract dendritic cells (RTDCs) efficiently endocytose soluble antigens, migrate to regional lymph nodes and present peptide to T cells that subsequently become tolerant. This article describes protocols for inducing tolerance via the naso-respiratory tract in experimental autoimmune uveoretinitis (EAU); for the isolation of RTDCs to facilitate definition of, and conditions for, maturation and activation of cells; and to test RTDC ability to induce tolerance in murine EAU when adoptively transferred. (c) 2005 Elsevier Inc. All rights reserved.

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收藏

页码：69 / 76

页数：8

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