Rating Method for Dilated Virchow-Robin Spaces on Magnetic Resonance Imaging

被引：67

作者：

Adams, Hieab H. H. ^{[1
]}

Cavalieri, Margherita ^{[3
]}

Verhaaren, Benjamin F. J. ^{[1
,2
]}

Bos, Daniel ^{[1
,2
]}

van der Lugt, Aad ^{[2
]}

Enzinger, Christian ^{[3
,4
]}

Vernooij, Meike W. ^{[1
,2
]}

Schmidt, Reinhold ^{[3
]}

Ikram, M. Arfan ^{[1
,2
]}

机构：

[1] Erasmus MC, Dept Epidemiol, NL-3015 GE Rotterdam, Netherlands

[2] Erasmus MC, Dept Radiol, NL-3015 GE Rotterdam, Netherlands

[3] Med Univ Graz, Dept Neurol, Graz, Austria

[4] Med Univ Graz, Dept Radiol, Graz, Austria

来源：

STROKE | 2013年 / 44卷 / 06期

关键词：

epidemiology; MRI; population-based study; Virchow-Robin spaces; COGNITIVE IMPAIRMENT; DEMENTIA; DISEASE; MRI; DILATATION; SEVERITY;

D O I：

10.1161/STROKEAHA.111.000620

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-Dilated Virchow-Robin spaces are an emerging neuroimaging biomarker, but their assessment on MRI needs standardization. Methods-We developed a rating method for dilated Virchow-Robin spaces in 4 brain regions (centrum semiovale, basal ganglia, hippocampus, and mesencephalon) and tested its reliability in a total of 125 MRI scans from 2 population-based studies. Six investigators with varying levels of experience performed the ratings. Intraclass correlation coefficients were calculated to determine intra- and interrater reliability. Results-Intrarater reliability was excellent for all 4 regions (intraclass correlation coefficient, >0.8). Interrater reliability was excellent for the centrum semiovale and hippocampus (intraclass correlation coefficient, >0.8) and good for the basal ganglia and mesencephalon (intraclass correlation coefficient, 0.6-0.8). This did not differ between the cohorts or experience levels. Conclusions-We describe a reliable rating method that can facilitate pathogenic and prognostic research on dilated Virchow-Robin spaces using MRI.

引用

页码：1732 / +

页数：9

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