Additional amplifications of SERS via an optofluidic CD-based platform

被引:61
作者
Choi, Dukhyun [1 ]
Kang, Taewook [2 ]
Cho, Hansang [1 ]
Choi, Yeonho [1 ]
Lee, Luke P. [1 ]
机构
[1] Univ Calif Berkeley, Dept Bioengn, Berkeley Sensor & Actuator Ctr, Biomol Nanotechnol Ctr, Berkeley, CA 94720 USA
[2] Sogang Univ, Dept Chem & Biomol Engn, Seoul 121742, South Korea
关键词
ENHANCED RAMAN-SCATTERING; NANOPARTICLE ARRAYS; SPECTROSCOPY; SILVER; MOLECULES; AGGREGATION;
D O I
10.1039/b812067f
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
In this paper, signal amplifications of surface-enhanced Raman scattering (SERS) are realized by an optofluidic compact disc (CD)-based preconcentration method for effective label-free environmental and biomolecular detections. The preconcentration of target molecules is accomplished through the accumulation of adsorbed molecules on SERS-active sites by repeating a 'filling-drying' cycle of the assay solution in the optofluidic CD platform. After 30 cycles, the clear and high SERS signal of rhodamine 6G of 1 nM is readily detected. In addition to the preconcentration-based signal amplification by the optofluidic SERS system on the CD platform, we introduce a controlled precipitation of gold nanoparticles by CuSO4 for SERS substrates. This method provides high-throughput, high-sensitive and large-area uniform SERS substrates on the optofluidic CD platform. The uniform SERS signals from different positions in spots of 3 mm 2 on the different CDs gives us confidence in the reliability and stability of our SERS substrates.
引用
收藏
页码:239 / 243
页数:5
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