Nanofluidic biosensing for β-amyloid detection using surface enhanced Raman spectroscopy

被引：179

作者：

Chou, I-Hsien ^{[1
]}

Benford, Melodie ^{[1
]}

Beier, Hope T. ^{[1
]}

Cote, Gerard L. ^{[1
]}

Wang, Miao ^{[2
]}

Jing, Nan ^{[2
]}

Kameoka, Jun ^{[2
]}

Good, Theresa A. ^{[3
]}

机构：

[1] Texas A&M Univ, Dept Biomed Engn, College Stn, TX 77843 USA

[2] Texas A&M Univ, Dept Elect Engn, College Stn, TX 77843 USA

[3] Univ Maryland Baltimore Cty, Dept Chem & Biochem Engn, Baltimore, MD 21250 USA

来源：

NANO LETTERS | 2008年 / 8卷 / 06期

关键词：

D O I：

10.1021/nl0808132

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Trace detection of the conformational transition of beta-amyloid peptide (A beta) from a predominantly alpha-helical structure to beta-sheet could have a large impact in understanding and diagnosing Alzheimer's disease. We demonstrate how a novel nanofluidic biosensor using a controlled, reproducible surface enhanced Raman spectroscopy active site was developed to observe A beta in different conformational states during the A beta self-assembly process as well as to distinguish A beta from confounder proteins commonly found in cerebral spinal fluid.

引用

页码：1729 / 1735

页数：7

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