Nanofluidic biosensing for β-amyloid detection using surface enhanced Raman spectroscopy

被引：179

作者：

Chou, I-Hsien ^{[1
]}

Benford, Melodie ^{[1
]}

Beier, Hope T. ^{[1
]}

Cote, Gerard L. ^{[1
]}

Wang, Miao ^{[2
]}

Jing, Nan ^{[2
]}

Kameoka, Jun ^{[2
]}

Good, Theresa A. ^{[3
]}

机构：

[1] Texas A&M Univ, Dept Biomed Engn, College Stn, TX 77843 USA

[2] Texas A&M Univ, Dept Elect Engn, College Stn, TX 77843 USA

[3] Univ Maryland Baltimore Cty, Dept Chem & Biochem Engn, Baltimore, MD 21250 USA

来源：

NANO LETTERS | 2008年 / 8卷 / 06期

关键词：

D O I：

10.1021/nl0808132

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Trace detection of the conformational transition of beta-amyloid peptide (A beta) from a predominantly alpha-helical structure to beta-sheet could have a large impact in understanding and diagnosing Alzheimer's disease. We demonstrate how a novel nanofluidic biosensor using a controlled, reproducible surface enhanced Raman spectroscopy active site was developed to observe A beta in different conformational states during the A beta self-assembly process as well as to distinguish A beta from confounder proteins commonly found in cerebral spinal fluid.

引用

页码：1729 / 1735

页数：7

共 48 条

[31] Identification of insulin variants using Raman spectroscopy [J].

Ortiz, C ;

Zhang, DM ;

Xie, Y ;

Davisson, VJ ;

Ben-Amotz, D .

ANALYTICAL BIOCHEMISTRY, 2004, 332 (02) :245-252

[32] Experimental constraints on quaternary structure in Alzheimer's β-amyloid fibrils [J].

Petkova, AT ;

Yau, WM ;

Tycko, R .

BIOCHEMISTRY, 2006, 45 (02) :498-512

[33] Part I: Surface-enhanced Raman spectroscopy investigation of amino acids and their homodipeptides adsorbed on colloidal silver [J].

Podstawka, E ;

Ozaki, Y ;

Proniewicz, LM .

APPLIED SPECTROSCOPY, 2004, 58 (05) :570-580

[34] Heat-triggered conversion of protofibrils into mature amyloid fibrils of β2-microglobulin [J].

Sasahara, Kenji ;

Yagi, Hisashi ;

Naiki, Hironobu ;

Goto, Yuji .

BIOCHEMISTRY, 2007, 46 (11) :3286-3293

[35] Alzheimer's disease: Genes, proteins, and therapy [J].

Selkoe, DJ .

PHYSIOLOGICAL REVIEWS, 2001, 81 (02) :741-766

[36] Scanning cysteine mutagenesis analysis of Aβ-(1-40) amyloid fibrils [J].

Shivaprasad, S ;

Wetzel, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (02) :993-1000

[37] Structure of amyloid β fragments in aqueous environments [J].

Takano, K ;

Endo, S ;

Mukaiyama, A ;

Chon, H ;

Matsumura, H ;

Koga, Y ;

Kanaya, S .

FEBS JOURNAL, 2006, 273 (01) :150-158

[38] Review:: Alzheimer's amyloid β-peptide-associated free radical oxidative stress and neurotoxicity [J].

Varadarajan, S ;

Yatin, S ;

Aksenova, M ;

Butterfield, DA .

JOURNAL OF STRUCTURAL BIOLOGY, 2000, 130 (2-3) :184-208

[39] An optofluidic device for surface enhanced Raman spectroscopy [J].

Wang, Miao ;

Jing, Nan ;

Chou, I-Hsien ;

Cote, Gerard L. ;

Kameoka, Jun .

LAB ON A CHIP, 2007, 7 (05) :630-632

[40] Hydrogen exchange-mass spectrometry analysis of β-Amyloid peptide structure [J].

Wang, SSS ;

Tobler, SA ;

Good, TA ;

Fernandez, EJ .

BIOCHEMISTRY, 2003, 42 (31) :9507-9514

← 1 2 3 4 5 →