Alkaline protease from Bacillus subtilis catalyzed Michael addition of pyrimidine derivatives to α,β-ethylenic compounds in organic media

被引：62

作者：

Cai, Y ^{[1
]}

Sun, XF ^{[1
]}

Wang, N ^{[1
]}

Lin, XF ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2004年 / 05期

关键词：

enzymes; nucleobases; Michael additions; catalysis; alkaline protease;

D O I：

10.1055/s-2004-815982

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Michael addition reactions of pyrimidine derivatives to alpha,beta-ethylenic compounds were catalyzed by an alkaline protease from Bacillus subtilis in DMSO at 50degreesC. The structure of adducts were determined by IR, NMR and MS. The yields were from 20% to 84%.

引用

页码：671 / 674

页数：4

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