Michael addition of nitromethane to non-racemic chiral Cr(CO)3 complexes of ethyl cinnamate derivatives:: stereoselective synthesis of (R)-(-)-baclofen

被引：34

作者：

Baldoli, C

Maiorana, S

Licandro, E

Perdicchia, D

Vandoni, B

机构：

[1] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy

[2] CNR, Ctr Studio Sintesi Stereochim Speciali Sistmi Org, I-20133 Milan, Italy

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 09期

关键词：

D O I：

10.1016/S0957-4166(00)00123-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We carried out a highly stereoselective Michael addition (96% de) of nitromethane to enantiomerically pure tricarbonyl (ethyl-4-chloro-2-trimethylsilylcinnamate)chromium(0). This reaction is the key step in the synthesis of(R)-(-)-baclofen, a potent antispastic drug. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2007 / 2014

页数：8

共 35 条

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Perdicchia, D
Vandoni, B
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