Porins from Salmonella enterica serovar typhimurium induce TNF-α, IL-6 and IL-8 release by CD14-independent and CD11a/CD18-dependent mechanisms

被引：22

作者：

Galdiero, M ^{[1
]}

D'Isanto, M ^{[1
]}

Vitiello, M ^{[1
]}

Finamore, E ^{[1
]}

Peluso, L ^{[1
]}

Galdiero, M ^{[1
]}

机构：

[1] Univ Naples 2, Fac Med & Chirurg, Ist Microbiol, I-80138 Naples, Italy

来源：

MICROBIOLOGY-SGM | 2001年 / 147卷

关键词：

Salmonella typhimurium; lipopolysaccharide; cytokines; integrins; cellular receptors;

D O I：

10.1099/00221287-147-10-2697

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Lipopolysaccharide (LPS) of Gram-negative bacteria and several surface components of Gram-positive bacteria utilize CD14 and CD11a/18 as cellular receptors to induce expression and release of cytokines. of the surface components of Gram-negative bacteria, porins exhibit a biological activity similar to that of LPS. The results in this paper show that the mechanism of stimulation by porins of THP-1 cells enriched in CD14 receptor after treatment with 1,25-dihydroxyvitamin D-3 (vitamin D-3) is independent of this receptor, but is partially dependent on CD11a/18 integrins.

引用

页码：2697 / 2704

页数：8

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