Non-alcoholic fatty liver disease and insulin resistance: From bench to bedside

被引：92

作者：

Gariani, K. ^{[1
]}

Philippe, J. ^{[1
]}

Jornayvaz, F. R. ^{[1
]}

机构：

[1] Univ Hosp Geneva, Serv Endocrinol Diabet Hypertens & Nutr, CH-1211 Geneva 14, Switzerland

来源：

DIABETES & METABOLISM | 2013年 / 39卷 / 01期

关键词：

Non-alcoholic fatty liver disease (NAFLD); Insulin resistance; Lipids; Mitochondrial dysfunction; Review; ACTIVATED PROTEIN-KINASE; ENDOPLASMIC-RETICULUM STRESS; RECEPTOR-GAMMA COACTIVATOR-1; PLECKSTRIN HOMOLOGY DOMAIN; HEPATIC STEATOSIS; SKELETAL-MUSCLE; ADIPOSE-TISSUE; MITOCHONDRIAL BIOGENESIS; NATURAL-HISTORY; CARDIOVASCULAR-DISEASE;

D O I：

10.1016/j.diabet.2012.11.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Non-alcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in the developed countries. There is also growing evidence from basic and clinical research that NAFLD has a strong relationship to insulin resistance, which is a key factor in the development of type 2 diabetes. The aim of this review is to summarize the recent important findings linking NAFLD and insulin resistance. Lipid accumulation, particularly of diacylglycerol, appears to be of major importance in this process. Mitochondrial dysfunction, through decreased mitochondrial biogenesis, increases oxidative stress, and ageing also plays an important role. Finally, endoplasmic reticulum stress and inflammation also probably contribute to the development of insulin resistance via mechanisms that are still not well understood. Clinical aspects of NAFLD, such as its diagnosis and management, are also investigated in this review. (C) 2012 Elsevier Masson SAS. All rights reserved.

引用

页码：16 / 26

页数：11

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