First total synthesis of isoprostane IPF2 alpha-III

被引：21

作者：

Adiyaman, M

Li, HW

Lawson, JA

Hwang, SW

Khanapure, SP

FitzGerald, GA

Rokach, J

机构：

[1] FLORIDA INST TECHNOL,CLAUDE PEPPER INST,MELBOURNE,FL 32901

[2] FLORIDA INST TECHNOL,DEPT CHEM,MELBOURNE,FL 32901

[3] UNIV PENN,CTR EXPT THERAPEUT,PHILADELPHIA,PA 19104

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(97)00622-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of IPF2 alpha-III, a type III isoprostane is described using a syn-anti-syn lactone 34 prepared from D-glucose and a novel iodohydrin synthon 30. This is first synthesis of a representative of type III isoprostane which is anticipated to be formed in vivo from arachidonic acid by free-radical mechanism. This synthetic material will help elucidate the formation in vivo of type III isoprostanes. (C) 1997 Elsevier Science Ltd.

引用

页码：3339 / 3342

页数：4