The coming of age of 1,25-dihydroxyvitamin D3 analogs as immunomodulatory agents

被引：380

作者：

Mathieu, C

Adorini, L ^{[1
]}

机构：

[1] Katholieke Univ Leuven, LEGENDO, Louvain, Belgium

[2] BioXell, I-20132 Milan, Italy

来源：

TRENDS IN MOLECULAR MEDICINE | 2002年 / 8卷 / 04期

关键词：

D O I：

10.1016/S1471-4914(02)02294-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The active form of vitamin D-3[1,25-dihydroxyvitamin D-3 [1,25(OH)(2)D-3], is a secosteroid hormone that regulates calcium and bone metabolism, controls cell proliferation and differentiation, and exerts immunoregulatory activities. This range of functions has been exploited clinically to treat a variety of conditions, from secondary hyperparathyroidism to osteoporosis, to autoimmune diseases such as psoriasis. Recent advances in understanding 1,25(OH)2 D. functions and novel insights into the mechanisms of its immunomodulatory properties suggest a wider applicability of this hormone in the treatment of autoimmune diseases and allograft rejection.

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收藏

页码：174 / 179

页数：6

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