What makes a drug a primary mood stabilizer?

被引：14

作者：

Keck, PE

McElroy, SL

Richtand, N

Tohen, M

机构：

[1] Univ Cincinnati, Coll Med, Dept Psychiat, Biol Psychiat Program, Cincinnati, OH 45267 USA

[2] Univ Cincinnati, Coll Med, Dept Psychiat, Cincinnati Vet Affairs Med Ctr, Cincinnati, OH USA

[3] Eli Lilly & Co, Indianapolis, IN 46285 USA

[4] Harvard Univ, Sch Med, Consolidated Dept Psychiat, Boston, MA USA

来源：

MOLECULAR PSYCHIATRY | 2002年 / 7卷 / Suppl 1期

关键词：

bipolar disorder; lithium; antiepileptics; atypical antipsychotics; mania; depression;

D O I：

10.1038/sj.mp.4001013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The term 'mood stabilizer' has been applied to a number of medications for the treatment of patients with bipolar disorder. The operational definition of the properties of a mood-stabilizing medication has varied according to the properties of specific medications and the clinical characteristics of the illness. Randomized controlled trials of agents accepted or proposed as mood stabilizers are reviewed to marshall the available evidence in support of this claim. In addition, potential pharmacological mechanisms underlying mood-stabilizing effects of established compounds are reviewed.

引用

页码：S8 / S14

页数：7

共 90 条

[1]

ANAND A, 1999, 3 INT C BIP DIS PITT, P23

[2]

ANAND A, 2000, MED PSYCHIATRY, V15, P59

[3]

[Anonymous], 2000, DIAGN STAT MAN MENT

[4]

BALLENGER JC, 1978, COMMUN PSYCHOPHARMAC, V2, P159

[5]

BANOV MD, 1994, J CLIN PSYCHIAT, V55, P295

[6] Response to clozapine in acute mania is more rapid than that of chlorpromazine [J].

Barbini, B ;

Scherillo, P ;

Benedetti, F ;

Crespi, G ;

Colombo, C ;

Smeraldi, E .

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 1997, 12 (02) :109-112

[7]

BLACKSHEAR MA, 1982, J PHARMACOL EXP THER, V221, P303

[8] A randomized, placebo-controlled 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder [J].

Bowden, CL ;

Calabrese, JR ;

McElroy, SL ;

Gyulai, L ;

Wassef, A ;

Petty, F ;

Pope, HG ;

Chou, JCY ;

Keck, PE ;

Rhodes, LJ ;

Swann, AC ;

Hirschfeld, RMA ;

Wozniak, PJ .

ARCHIVES OF GENERAL PSYCHIATRY, 2000, 57 (05) :481-489

[9] EFFICACY OF DIVALPROEX VS LITHIUM AND PLACEBO IN THE TREATMENT OF MANIA [J].

BOWDEN, CL ;

BRUGGER, AM ;

SWANN, AC ;

CALABRESE, JR ;

JANICAK, PG ;

PETTY, F ;

DILSAVER, SC ;

DAVIS, JM ;

RUSH, AJ ;

SMALL, JG ;

GARZATREVINO, ES ;

RISCH, SC ;

GOODNICK, PJ ;

MORRIS, DD .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 271 (12) :918-924

[10] LONG-TERM RANDOMIZED CLINICAL-TRIAL ON OXCARBAZEPINE VS LITHIUM IN BIPOLAR AND SCHIZOAFFECTIVE DISORDERS - PRELIMINARY-RESULTS [J].

CABRERA, JF ;

MUHLBAUER, HD ;

SCHLEY, J ;

STOLL, KD ;

MULLEROERLINGHAUSEN, B .

PHARMACOPSYCHIATRY, 1986, 19 (04) :282-283

← 1 2 3 4 5 6 7 8 9 →