What makes a drug a primary mood stabilizer?

被引：14

作者：

Keck, PE

McElroy, SL

Richtand, N

Tohen, M

机构：

[1] Univ Cincinnati, Coll Med, Dept Psychiat, Biol Psychiat Program, Cincinnati, OH 45267 USA

[2] Univ Cincinnati, Coll Med, Dept Psychiat, Cincinnati Vet Affairs Med Ctr, Cincinnati, OH USA

[3] Eli Lilly & Co, Indianapolis, IN 46285 USA

[4] Harvard Univ, Sch Med, Consolidated Dept Psychiat, Boston, MA USA

来源：

MOLECULAR PSYCHIATRY | 2002年 / 7卷 / Suppl 1期

关键词：

bipolar disorder; lithium; antiepileptics; atypical antipsychotics; mania; depression;

D O I：

10.1038/sj.mp.4001013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The term 'mood stabilizer' has been applied to a number of medications for the treatment of patients with bipolar disorder. The operational definition of the properties of a mood-stabilizing medication has varied according to the properties of specific medications and the clinical characteristics of the illness. Randomized controlled trials of agents accepted or proposed as mood stabilizers are reviewed to marshall the available evidence in support of this claim. In addition, potential pharmacological mechanisms underlying mood-stabilizing effects of established compounds are reviewed.

引用

页码：S8 / S14

页数：7

共 90 条

[21]

DUNNER DL, 1974, ARCH GEN PSYCHIAT, V30, P229

[22]

EMRICH HM, 1990, INT CLIN PSYCHOPHARM, V5, P83

[23] A placebo-controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders [J].

Frye, MA ;

Ketter, TA ;

Kimbrell, TA ;

Dunn, RT ;

Speer, AM ;

Osuch, EA ;

Luckenbaugh, DA ;

Corá-Locatelli, G ;

Leverich, GS ;

Post, RM .

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2000, 20 (06) :607-614

[24] Clozapine in bipolar disorder:: treatment implications for other atypical antipsychotics [J].

Frye, MA ;

Ketter, TA ;

Altshuler, LL ;

Denicoff, K ;

Dunn, RT ;

Kimbrell, TA ;

Corá-Locatelli, G ;

Post, RM .

JOURNAL OF AFFECTIVE DISORDERS, 1998, 48 (2-3) :91-104

[25]

Ghaemi S N, 1999, Ann Clin Psychiatry, V11, P137, DOI 10.3109/10401239909147062

[26]

Ghaemi SN, 2000, BIPOLAR DISORD, V2, P196

[27] Long-term risperidone treatment in bipolar disorder: 6-month follow up [J].

Ghaemi, SN ;

Sachs, GS .

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 1997, 12 (06) :333-338

[28]

Goodwin F.K., 2007, MANIC DEPRESSIVE ILL

[29] Lithium versus carbamazepine in the maintenance treatment of bipolar disorders - A randomised study [J].

Greil, W ;

LudwigMayerhofer, W ;

Erazo, N ;

Schochlin, C ;

Schmidt, S ;

Engel, RR ;

Czernik, A ;

Giedke, H ;

MullerOerlinghausen, B ;

Osteheider, M ;

Rudolf, GAE ;

Sauer, H ;

Tegeler, J ;

Wetterling, T .

JOURNAL OF AFFECTIVE DISORDERS, 1997, 43 (02) :151-161

[30]

GROSSI E, 1984, ANTICONVULSANTS AFFE, P177

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