Regulation of plasminogen activator inhibitor type 1 gene expression by inflammatory mediators and statins

被引：90

作者：

Kruithof, Egbert K. O. ^{[1
]}

机构：

[1] Univ Hosp Geneva, Div Angiol & Hemostasis, CH-1211 Geneva, Switzerland

来源：

THROMBOSIS AND HAEMOSTASIS | 2008年 / 100卷 / 06期

关键词：

Plasminogen activator inhibitor type 1; gene regulation; inflammation; statins;

D O I：

10.1160/TH08-04-0269

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Elevated plasma concentrations of plasminogen activator inhibitor type 1 (PAI-1), also named serpin E1, are encountered in patients with thrombophilia, atherosclerosis, septicemia and the metabolic syndrome and may be associated with an increased risk of complications. Expression of PAI-1 is increased by inflammatory stimuli and decreased by statins, drugs widely used in patients with cardiovascular disease. Increased expression of PAI-1 by inflammatory stimuli is mediated by a large variety of signal transduction pathways, which include the NF-kappa B and MAP kinase pathways. The downregulating effect of statins on PAI-1 expression is dependent on the inhibition of Rho family proteins and may involve an activation of PI-3 kinase/Akt signaling pathways. In this review we summarize the findings on the effect of inflammation and statins on PAI-1 expression.

引用

页码：969 / 975

页数：7

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