MRI evaluation of thermal ablation of tumors with focused ultrasound

被引:136
作者
McDannold, N [1 ]
Hynynen, K [1 ]
Wolf, D [1 ]
Wolf, G [1 ]
Jolesz, F [1 ]
机构
[1] Tufts Univ, Dept Phys & Astron, Medford, MA 02155 USA
来源
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1998年 / 8卷 / 01期
关键词
ultrasound; focused ultrasound; MRI; MRI thermometry; tumor ablation; hyperthermia;
D O I
10.1002/jmri.1880080119
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
MRI was used to target and evaluate the tissue effects of focused ultrasound ablation on tumors implanted in the skeletal muscle of rabbits in vivo. First, MRI was used to localize the tumors and plan the ultrasound therapy, Second, temperature-sensitive phase-difference images were acquired to monitor the location of the ultrasound focus and to estimate the effects of temperature rise. After the treatment, the spatial and temporal temperature profiles for defining boundaries of tissue coagulation were calculated, Finally, these boundaries were compared to Ta-weighted and contrast-enhanced T1-weighted images obtained immediately after therapy. The results indicate that using MRI for planning and evaluating focused ultrasound surgery is feasible. We showed a linear relationship between applied power and shifts in the proton resonant frequency, Fluctuations in the location of the focus about the target location were on the order of the resolution of the MR images, The temperature rise and lesion size varied significantly. Regions of tissue coagulation calculated from MR data correlated well with post-therapy imaging.
引用
收藏
页码:91 / 100
页数:10
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