Chapter 11: Genome-Wide Association Studies

被引：742

作者：

Bush, William S. ^{[1
]}

Moore, Jason H. ^{[2
,3
]}

机构：

[1] Vanderbilt Univ, Sch Med, Dept Biomed Informat, Ctr Human Genet Res, Nashville, TN 37212 USA

[2] Dartmouth Med Sch, Inst Quantitat Biomed Sci, Dept Genet, Lebanon, NH USA

[3] Dartmouth Med Sch, Inst Quantitat Biomed Sci, Dept Community Family Med, Lebanon, NH USA

来源：

PLOS COMPUTATIONAL BIOLOGY | 2012年 / 8卷 / 12期

关键词：

FACTOR-H POLYMORPHISM; MACULAR DEGENERATION; GENOTYPE IMPUTATION; MULTIPLE-SCLEROSIS; COMMON DISEASES; LOCI; RISK; METAANALYSIS; TRAITS; GENE;

D O I：

10.1371/journal.pcbi.1002822

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Genome-wide association studies (GWAS) have evolved over the last ten years into a powerful tool for investigating the genetic architecture of human disease. In this work, we review the key concepts underlying GWAS, including the architecture of common diseases, the structure of common human genetic variation, technologies for capturing genetic information, study designs, and the statistical methods used for data analysis. We also look forward to the future beyond GWAS.

引用

页数：11

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