suppressor network;
anoikis;
systems biology;
prostate cancer;
tumor progression;
D O I:
10.1038/sj.cgt.7700896
中图分类号:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号:
071005 ;
0836 ;
090102 ;
100705 ;
摘要:
Recent studies are reviewed indicating that the transcription factor early growth response-1 (Egr1) is a direct regulator of multiple tumor suppressors including TGF beta 1, PTEN, p53, and fibronectin. The downstream pathways of these factors display multiple nodes of interaction with each other, suggesting the existence of a functional network of suppressor factors that serve to maintain normal growth regulation and resist the emergence of transformed variants. Paradoxically, Egr1 is oncogenic in prostate cancer. In the majority of these cancers, PTEN or p53 is inactive. It is suggested that these defects in the suppressor network allow for the unopposed induction of TGF beta 1 and fibronectin, which favor transformation and survival of prostate tumor epithelial cells, and explain the role of Egr1 in prostate cancer. Egr1 is a novel and logical target for intervention by gene therapy methods, and targeting methods are discussed.
机构:
Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
IRCCS Neuromed, I-86077 Pozzilli, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Calogero, Antonella
Lombari, Vincenza
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS Neuromed, I-86077 Pozzilli, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Lombari, Vincenza
De Gregorio, Giorgia
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS Neuromed, I-86077 Pozzilli, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
De Gregorio, Giorgia
Porcellini, Antonio
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
IRCCS Neuromed, I-86077 Pozzilli, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Porcellini, Antonio
Ucci, Severine
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Ucci, Severine
Arcella, Antonietta
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS Neuromed, I-86077 Pozzilli, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Arcella, Antonietta
Caruso, Riccardo
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS Neuromed, I-86077 Pozzilli, Italy
Univ Roma La Sapienza, Dept Neurol Sci, I-00161 Rome, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Caruso, Riccardo
Gagliardi, Franco Maria
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS Neuromed, I-86077 Pozzilli, Italy
Univ Roma La Sapienza, Dept Neurol Sci, I-00161 Rome, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Gagliardi, Franco Maria
Gulino, Alberto
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Gulino, Alberto
Lanzetta, Gaetano
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS Neuromed, I-86077 Pozzilli, Italy
INI, I-00046 Grottaferrata, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Lanzetta, Gaetano
Frati, Luigi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
IRCCS Neuromed, I-86077 Pozzilli, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Frati, Luigi
Mercola, Dan
论文数: 0引用数: 0
h-index: 0
机构:
Sidney Kimmel Canc Ctr, San Diego, CA 92121 USA
Univ Calif San Diego, Ctr Canc, La Jolla, CA 92093 USAUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Mercola, Dan
Ragona, Giuseppe
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
IRCCS Neuromed, I-86077 Pozzilli, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
机构:
Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
IRCCS Neuromed, I-86077 Pozzilli, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Calogero, Antonella
Lombari, Vincenza
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS Neuromed, I-86077 Pozzilli, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Lombari, Vincenza
De Gregorio, Giorgia
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS Neuromed, I-86077 Pozzilli, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
De Gregorio, Giorgia
Porcellini, Antonio
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
IRCCS Neuromed, I-86077 Pozzilli, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Porcellini, Antonio
Ucci, Severine
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Ucci, Severine
Arcella, Antonietta
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS Neuromed, I-86077 Pozzilli, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Arcella, Antonietta
Caruso, Riccardo
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS Neuromed, I-86077 Pozzilli, Italy
Univ Roma La Sapienza, Dept Neurol Sci, I-00161 Rome, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Caruso, Riccardo
Gagliardi, Franco Maria
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS Neuromed, I-86077 Pozzilli, Italy
Univ Roma La Sapienza, Dept Neurol Sci, I-00161 Rome, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Gagliardi, Franco Maria
Gulino, Alberto
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Gulino, Alberto
Lanzetta, Gaetano
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS Neuromed, I-86077 Pozzilli, Italy
INI, I-00046 Grottaferrata, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Lanzetta, Gaetano
Frati, Luigi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
IRCCS Neuromed, I-86077 Pozzilli, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Frati, Luigi
Mercola, Dan
论文数: 0引用数: 0
h-index: 0
机构:
Sidney Kimmel Canc Ctr, San Diego, CA 92121 USA
Univ Calif San Diego, Ctr Canc, La Jolla, CA 92093 USAUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
Mercola, Dan
Ragona, Giuseppe
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
IRCCS Neuromed, I-86077 Pozzilli, ItalyUniv Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy